FGFR inhibitor JNJ-42756493, Purity ≥98%

Synonym: 1346242-81-6; FGFR inhibitor; JNJ 42756493; JNJ42756493; JNJ-42756493

MDL: MFCD28502040
CAS Number: 1346242-81-6
Compound CID: 67462786

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

JNJ-42756493, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR3, and FGFR4.

Molecular Weight

446.55

Molecular Formula

C₂₅H₃₀N₆O₂

Targets

FGFR1: 1.2 nM; FGFR2: 2.5 nM; FGFR3: 3.0 nM; FGFR4: 5.7 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 79 mg/mL (176.92 mM); Water: Insoluble; Ethanol: 79 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

JNJ-42756493 is applied in investigating FGFR inhibition in cancer research, specifically for targeting tumors that exhibit FGFR pathway activation.