Cat. No.: X23-10-ZQ473
FGFR inhibitor KW-2449, Purity ≥98%
Synonym: KW-2449; 1000669-72-6; KW 2449; KW2449; 841258-76-2; (E)-(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone; [4-[(E)-2-(1H-Indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone; FGFR inhibitor
- MDL: MFCD18385006
- CAS Number: 1000669-72-6
- Compound CID: 11427553
Product Size
10 mg; 25 mg; 50 mg; 100 mg; 200 mg
Properties
Description
KW-2449, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets Abl (T315I), FLT3, FLT3, Aurora A, FGFR1, FLT3 (D835Y), JAK2, Kit, PDGFRα, and Src.
Molecular Formula
C20H20N4O
Targets
Abl (T315I): 4 nM; FLT3: 6.6 nM; FLT3: 14 nM; Aurora A: 48 nM; FGFR1: 36 nM; FLT3 (D835Y): 1 nM; JAK2: 150 nM; Kit: 300 nM; PDGFRα: 1.7 μM; Src: 400 nM
Solubility
DMSO: 58 mg/mL (174.48 mM); Water: Insoluble; Ethanol: 58 mg/mL (174.48 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
KW-2449 can be applied to examine inhibition of Aurora kinase A and FLT3 in leukemia research.
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