FGFR inhibitor KW-2449, Purity ≥98%

Synonym: KW-2449; 1000669-72-6; KW 2449; KW2449; 841258-76-2; (E)-(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone; [4-[(E)-2-(1H-Indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone; FGFR inhibitor

MDL: MFCD18385006
CAS Number: 1000669-72-6
Compound CID: 11427553

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

KW-2449, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets Abl (T315I), FLT3, FLT3, Aurora A, FGFR1, FLT3 (D835Y), JAK2, Kit, PDGFRα, and Src.

Molecular Weight

332.4

Molecular Formula

C₂₀H₂₀N₄O

Targets

Abl (T315I): 4 nM; FLT3: 6.6 nM; FLT3: 14 nM; Aurora A: 48 nM; FGFR1: 36 nM; FLT3 (D835Y): 1 nM; JAK2: 150 nM; Kit: 300 nM; PDGFRα: 1.7 μM; Src: 400 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 58 mg/mL (174.48 mM); Water: Insoluble; Ethanol: 58 mg/mL (174.48 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

KW-2449 can be applied to examine inhibition of Aurora kinase A and FLT3 in leukemia research.