FGFR inhibitor LY 2874455, Purity ≥98%

Synonym: 1254473-64-7; FGFR inhibitor; LY-2874455; LY2874455

CAS Number: 1254473-64-7
Compound CID: 46944259

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY 2874455, soluble in DMSO and warmed ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR3, FGFR4, and VEGFR2.

Molecular Weight

444.31

Molecular Formula

C₂₁H₁₉Cl₂N₅O₂

Targets

FGFR1: 2.8 nM; FGFR2: 2.6 nM; FGFR3: 6.4 nM; FGFR4: 6 nM; VEGFR2: 7 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (193.55 mM); Water: Insoluble; Warmed ethanol: 56 mg/mL (126.03 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

LY 2874455 is applied in FGFR research, serving as a selective inhibitor to help elucidate FGFR’s role in cancer development.