FGFR inhibitor MK-2461, Purity ≥98%

Synonym: 917879-39-1; FGFR inhibitor; MK2461

CAS Number: 917879-39-1
Compound CID: 44137946

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MK-2461, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets c-Met (Y1230H), c-Met (Y1235D), Abl, c-Met, c-Met(M1250T), c-Met(N1100), c-Met(Y1230C), DRAK1, DRAK2, FGFR1, and FGFR2.

Molecular Weight

495.6

Molecular Formula

C₂₄H₂₅N₅O₅S

Targets

c-Met (Y1230H): 1.0 nM; c-Met (Y1235D): 0.5 nM; Abl: 7.747 μM; c-Met: 2.5 nM; c-Met (M1250T): 0.4 nM; c-Met (N1100): 1.5 nM; c-Met (Y1230C): 1.5 nM; DRAK1: 199 nM; DRAK2: 1.143 nM; FGFR1: 65 nM; FGFR2: 39 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 95 mg/mL (191.7 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

MK-2461 aids in cancer research targeting FGFR, focusing on inhibiting its activity to explore therapeutic options for FGFR-driven cancers.