FGFR inhibitor Nintedanib esylate, Purity ≥98%

Synonym: 656247-18-6; FGFR inhibitor; BIBF-1120 esylate

MDL: MFCD26142360
CAS Number: 656247-18-6
Compound CID: 135476717

Product Size

10 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nintedanib esylate, soluble in DMSO, water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR3, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, and VEGFR3.

Molecular Weight

649.76

Molecular Formula

C₃₃H₃₉N₅O₇S

Targets

FGFR1: 69 nM; FGFR2: 37 nM; FGFR3: 108 nM; PDGFRα: 59 nM; PDGFRβ: 65 nM; VEGFR1: 34 nM; VEGFR2: 13 nM; VEGFR3: 13 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (136.97 mM); Water: 89 mg/mL (136.97 mM); Ethanol: 4 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Nintedanib esylate is used to inhibit FGFR in research, contributing to the understanding of FGFR’s involvement in fibrotic and cancerous diseases.