FGFR inhibitor Pemigatinib, Purity ≥98%

Synonym: 1513857-77-6; FGFR inhibitor; INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828

MDL: MFCD31706227
CAS Number: 1513857-77-6
Compound CID: 86705695

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pemigatinib, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR3, and FGFR4.

Molecular Weight

487.5

Molecular Formula

C₂₄H₂₇F₂N₅O₄

Targets

FGFR1: 0.4 nM; FGFR2: 0.5 nM; FGFR3: 1.2 nM; FGFR4: 30 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 38 mg/mL (77.95 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pemigatinib is utilized as an FGFR inhibitor in research, focusing on tumors with FGFR genetic alterations to understand its therapeutic efficacy.