FGFR inhibitor XL-228, Purity ≥98%

Synonym: XL228; XL-228; 898280-07-4; XL 228; 4-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine; Exel-2280; 33M2XSK003; FGFR inhibitor

CAS Number: 898280-07-4
Compound CID: 59757974

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

XL-228, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets Aurora A and IGF-1R.

Molecular Weight

437.5

Molecular Formula

C₂₂H₃₁N₉O

Targets

Aurora A: 3.1 nM; IGF-1R: 1.6 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 79 mg/mL (180.55 mM); Water: Insoluble; Ethanol: 27 mg/mL (61.7 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

XL-228 is useful in analyzing the effects of multi-kinase inhibition, including Aurora kinases, on cancer cells.