Properties
Description
Fingolimod, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets PAK1, and S1P.
Molecular Formula
C19H33NO2
Targets
PAK1; S1P: 0.033 nM (IC50, in K562 and NK cells)
Solubility
DMSO: 12 mg/mL (39.03 mM); Water: insoluble; Ethanol: 5 mg/mL (16.26 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Fingolimod can be used for its ability to reduce the frequency of relapses, slow down the progression of disability, and decrease the number of brain lesions detected on MRI scans.
Storage
Store at -20°C, and keep desiccated.
