Properties
Description
Flibanserin, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A receptor, 5-HT2A receptor, and dopamine D4 receptors.
Molecular Formula
C20H21F3N4O
Targets
5-HT1A receptor: 1 nM; 5-HT2A receptor: 49 nM; dopamine D4 receptors: 4-24 nM
Solubility
DMSO: 70 mg/mL (179.3 mM); Water: insoluble; Ethanol: 21 mg/mL (53.79 mM)
Applications
Flibanserin can be used for its ability to increase sexual desire and improve sexual satisfaction.