Properties
Description
AC220, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3 (ITD) (MV4-11 cells), and FLT3 (WT).
Molecular Formula
C29H32N6O4S
Targets
FLT3 (ITD): 1.1 nM; FLT3 (WT): 4.2 nM
Solubility
DMSO: 29 mg/mL (51.72 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
AC220 acts as a FLT3 inhibitor in leukemia studies, providing insights into the disruption of aberrant cellular signaling.
