FLT3 inhibitor G-749, Purity ≥98%

Synonym: 1457983-28-6; FLT3 inhibitor; G749

MDL: MFCD28167815
CAS Number: 1457983-28-6
Compound CID: 78357765

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

G-749, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3 (D835Y), Mer, Aurora B, AuroraC, Axl, c-Kit, FGFR1, FGFR3, FLT3, Fms, and IGF-1R.

Molecular Weight

521.41

Molecular Formula

C₂₅H₂₅BrN₆O₂

Targets

FLT3 (D835Y): 0.6 nM; Mer: 1 nM; AuroraB: 6 nM; AuroraC: 24 nM; Axl: 20 nM; c-Kit: 142 nM; FGFR1: 25 nM; FGFR3: 30 nM; FLT3: 0.4 nM; Fms: 19 nM; IGF-1R: >300 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 22 mg/mL (42.19 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

G-749 is used as a FLT3 inhibitor in cancer studies exploring its effects on disrupting leukemia cell signaling.