FLT3 inhibitor Go 6976, Purity ≥98%

Synonym: 136194-77-9; Go 6976; GO6976; Go-6976; Goe 6976; 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile; 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile; FLT3 inhibitor

CAS Number: 136194-77-9
Compound CID: 3501

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Go 6976, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3, JAK2, PKC (Rat brain), PKCα, and PKCα.

Molecular Weight

378.43

Molecular Formula

C₂₄H₁₈N₄O

Targets

FLT3; JAK2; PKC (Rat brain): 7.9 nM; PKCα: 2.3 nM; PKCα: 6.2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 18 mg/mL (47.69 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Go 6976 can be used to investigate the inhibition of protein kinase C (PKC) isozymes, specifically PKCα and PKCβ.

Storage

Store at -20ºC.