FLT3 inhibitor MLN518, Purity ≥98%

Synonym: 387867-13-2; FLT3 inhibitor; MLN-518; CT53518

MDL: MFCD09954147
CAS Number: 387867-13-2
Compound CID: 3038522

Product Size

25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

MSDS

Properties

Description

MLN518, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets Flt3, PDGFRβ, Abl, c-Kit, CSF-1R, EGFR, ERK2, FGFR, Insulin receptor, KDR, and MEK1.

Molecular Weight

562.7

Molecular Formula

C₃₁H₄₂N₆O₄

Targets

Flt3: 0.22 μM; PDGFRβ: 0.2 μM; Abl: >30 μM; c-Kit: 0.17 μM; CSF-1R: 3.43 μM; EGFR: >30 μM; ERK2: >30 μM; FGFR: >30 μM; Insulin receptor: >30 μM; KDR: >30 μM; MEK1: >30 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 5 mg/mL (8.88 mM); Water: Insoluble; Ethanol: 6 mg/mL (10.66 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

MLN518 functions as a FLT3 inhibitor in research focused on interactions in leukemia pathogenesis and therapy.