FLT3 inhibitor Pacritinib, Purity ≥98%

Synonym: Pacritinib; 937272-79-2; Pacritinib (SB1518); SB1518; SB-1518; ONX-0803; SB 1518; FLT3 inhibitor

MDL: MFCD22572772
CAS Number: 937272-79-2
Compound CID: 46216796

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pacritinib, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3-D835Y, FLT3 wt, JAK1, JAK2 (V617F), JAK2wt, JAK3, and Tyk2.

Molecular Weight

472.58

Molecular Formula

C₂₈H₃₂N₄O₃

Targets

FLT3-D835Y: 6 nM; FLT3 wt: 22 nM; JAK1: 1280 nM; JAK2 (V617F): 19 nM; JAK2wt: 23 nM; JAK3: 520 nM; Tyk2: 50 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 10 mg/mL (21.15 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pacritinib is employed in studying the selective inhibition of JAK2 and FLT3 kinases.