FLT3 inhibitor Pacritinib, Purity ≥98%

Synonym: Pacritinib; 937272-79-2; Pacritinib (SB1518); SB1518; SB-1518; ONX-0803; SB 1518; FLT3 inhibitor

MDL: MFCD22572772
CAS Number: 937272-79-2
Compound CID: 46216796

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pacritinib, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3-D835Y, FLT3 wt, JAK1, JAK2 (V617F), JAK2wt, JAK3, and Tyk2.

Molecular Weight

472.58

Molecular Formula

C₂₈H₃₂N₄O₃

Targets

FLT3-D835Y: 6 nM; FLT3 wt: 22 nM; JAK1: 1280 nM; JAK2 (V617F): 19 nM; JAK2wt: 23 nM; JAK3: 520 nM; Tyk2: 50 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 10 mg/mL (21.15 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Pacritinib is employed in studying the selective inhibition of JAK2 and FLT3 kinases.

Storage

Store at -20ºC.