Properties
Description
PLX3397, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets CSF-1R, Flt3, and Kit.
Molecular Formula
C20H15ClF3N5
Targets
CSF-1R: 20 nM; Flt3: 160 nM; Kit: 10 nM
Solubility
DMSO: 71 mg/mL (169.93 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
PLX3397 functions as a multi-kinase inhibitor, including FLT3, for research into tumor microenvironment and cancer therapy.
