FLT3 inhibitor TG-101348, Purity ≥98%

Synonym: Fedratinib; 936091-26-8; Tg-101348; TG101348; SAR302503; SAR-302503; N-(tert-Butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide; FLT3 inhibitor

MDL: MFCD12922515
CAS Number: 936091-26-8
Compound CID: 16722836

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TG-101348, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FLT3. It targets FLT3, JAK2, JAK2 (V617F), and RET.

Molecular Weight

524.7

Molecular Formula

C₂₇H₃₆N₆O₃S

Targets

FLT3: 15 nM; JAK2: 3 nM; JAK2 (V617F): 3 nM; RET: 48 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (171.53 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

TG-101348 can be employed to study its JAK2 inhibition in myeloproliferative neoplasm research.