Glycosaminoglycan Inhibitor Development Service

Glycosaminoglycan (GAG) Inhibitor Development Service at CD BioGlyco

At CD BioGlyco, we meticulously attend to every aspect of Glycosylation Inhibitor Development, aiming for excellence in each step, as demonstrated by our extensive track record of success over the years. We provide numerous GAG inhibitor development services, including but not limited to the following:

Publication

Technology: Immunofluorescence staining, Bioinformatics analysis technology

Journal:Angewandte Chemie International Edition

IF: 16.823

Published: 2014

Results: This paper focuses on the use of a visualized chain termination inhibitor, UDP-4-azido-4-deoxyxylose (UDP-4-XylAz), to block GAG biosynthesis in developing zebrafish. Then the authors concluded that UDP-4-XylAz is a potent inhibitor of chain-terminating metabolism that inhibits GAG biosynthesis in zebrafish. The compound has the unique property of being able to visualize the site of its inhibitory action in vivo through a bioorthogonal reaction with fluorescent cyclooctyne. Differences in GAG content in UDP-4-XylAz-treated embryos compared to untreated embryos may contribute to the specific embryonic developmental defects observed.

Fig.1 Xylose initiates diverse GAG structures and can therefore be targeted for metabolic replacement with a visualizable chain-truncating analog. (Beahm, et al., 2014)

Applications

• GAG inhibitors can be used in cellular experiments in vitro and animal model studies to investigate the role of GAGs in biological processes.
• GAG inhibitors can modulate the angiogenic process and have potential applications in drug development in vascular abnormalities and vascular diseases such as hemangiomas.
• GAG inhibitors disrupt the inflammatory response, and as a result, they play a crucial role in the study of diseases like rheumatoid arthritis, asthma, and inflammatory bowel disease.

CD BioGlyco boasts expert inhibitor development teams and cutting-edge technology, offering clients unmatched GAG inhibitor development services and comprehensive post-sales support for research projects. We are confident in our ability to serve as your indispensable research partner in the field of glycobiology. For further information regarding our services, please feel free to contact us.