Applications of Galactan

Galactan is a non-synthetic oligosaccharide derived from animal milk. In nature, trace amounts of galactan exist in animal milk, while human breast milk contains more. It has the general properties of oligosaccharides, has good bifidobacteria proliferation activity, and is a high-quality prebiotic. Galactan possesses strong selectivity for proliferating probiotics, promoting the growth of lactobacilli and bifidobacteria, and at the same time inhibiting the growth of opportunistic pathogenic bacteria in the intestinal tract. Galactan can also regulate the intestinal flora of obese individuals and improve the symptoms of metabolic syndrome. Intake of galactan directly improves gastrointestinal symptoms and may be utilized in the treatment of gastrointestinal disorders such as bloating, gas, and abdominal pain.

Fig.1 Structure of galactan. (CD BioGlyco)

Galactan Analysis Service at CD BioGlyco

CD BioGlyco has many years of experience in the Analysis of Polysaccharides. We offer a full range of galactan analytical services. These include the purity and molecular weight analysis, the monosaccharide composition analysis, the conformation analysis, etc.

• Analysis of the purity and molecular weight
  We provide high-performance liquid chromatography (HPLC) for the purification of galactan and then analyze the purity and molecular weight of galactan using high-performance gel permeation chromatography (HP-GPC).
• Analysis of monosaccharide composition
  We offer the high-performance anion exchange chromatography (HPAEC) method. HPAEC utilizes the difference in ion exchange capacity or the difference in selectivity coefficient of the monosaccharide components to achieve separation and thus determine their monosaccharide composition.
• Analysis of configurations
  For the conformational analysis of galactans, we offer infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) spectroscopy. In this method, IR and ¹H NMR provide conformational information on the α- or β-hydrocarbons of the sugar, thus determining the sugar type.

Fig.2 Analysis of services related to galactans. (CD BioGlyco)

Publication

Paper Title: Microwave-assisted synthesis and structural analysis of galactan.

Technology: Infrared spectroscopy (IR)

Journal: Food Science

Published: 2014

Results: As can be seen from the figure below, the strong and broad absorption peaks at 3000-3700 cm^-1 are generated by the stretching vibration of O-H. The absorption peaks at 3406 cm^-1 and 2930 cm^-1 are generated by the stretching vibration of hydroxyl (-OH) and C-H stretching vibrations respectively, the absorption peaks at 1638 and 1572 cm^-1 are C=O and the absorption peak at 1,411 cm^-1 is C-O vibration generation. 1144, 1081, and 1036 cm^-1 are characteristic absorption peaks of galactans, and the absorption peaks at 875 cm^-1 and 797 cm^-1 indicate the presence of α- and β-configurations in galactans, and the small peak at 695 cm^-1 The small peak at 695 cm^-1 is the characteristic absorption peak of galactans.

Fig.3 IR spectrum of galactan. (Wang, et al., 2014)

Applications

• The galactan analysis can be used for carbohydrate drug development.
• The galactan analysis can be used for tumor research.
• The galactan analysis can be used to explore the structure of carbohydrates.

Advantages

• We have a comprehensive range of carbohydrate analysis methods, including structure, monosaccharide composition, purity analysis, and more.
• Our analytical methods are simple and efficient.
• In addition to analysis, we also offer carbohydrate modification services.

CD BioGlyco has extensive experience in the analysis of polysaccharides. We offer comprehensive galactan analysis services. These include but are not limited to purity, molecular weight, monosaccharide composition, and conformational analysis. If you are interested in our services, please feel free to contact us.