Prednisolone acetate, a synthetic glucocorticoid, acts as an anti-inflammatory and immunomodulating agent by binding to intracellular glucocorticoid receptors. This binding initiates the transcription of glucocorticoid-responsive genes, inhibiting phospholipase A2 and blocking the release of inflammatory mediators. Additionally, it induces cell differentiation, and apoptosis in tumor cells, and reduces circulating lymphocytes. Gentamicin, a bactericidal aminoglycoside, is effective against a broad spectrum of bacteria. Co-administration with other antibacterials, particularly beta-lactams, enhances its efficacy, though it is associated with nephrotoxicity and ototoxicity. CD BioGlyco offers a specialized gentamicin and prednisolone acetate ophthalmic ointment analysis service for the field of Pharmaceutical Analysis, ensuring precise evaluation of this pharmaceutical formulation. Our comprehensive analysis covers various aspects, including identification tests, content determination, impurity profiling, and specific tests.
Fig.1 The structure of gentamicin and prednisolone acetate (CD BioGlyco)
We take pride in our commitment to technological excellence, providing clients with the assurance that their pharmaceutical products undergo thorough scrutiny using cutting-edge methodologies. Our identification tests utilize thin-layer chromatography for accurate results. The gentamicin assay employs the antibiotics-microbial assay method, ensuring reliable quantification. For prednisolone acetate, we employ chromatography, especially chiral liquid chromatography (CL), for precise assay measurements. Additionally, our specific tests include a sterility test, ensuring the safety and quality of the ophthalmic ointment. Moreover, we also provide more than 90 Pharmaceutical and Biological Analysis services. Rely on CD BioGlyco for thorough and dependable pharmaceutical analysis services.
Fig.2 The content of gentamicin and prednisolone acetate ophthalmic ointment analysis. (CD BioGlyco)
Technology: Anti-inflammatory, Pyrazole derivatives, Benzimidazole derivativesIndole derivatives, Pyrimidine derivatives, Clinical trials
Journal: European Journal of Medicinal Chemistry
IF: 6.7
Published: 2020
Results: Inflammation is a vital immune response to cell or tissue damage, triggered by various stimuli such as injuries or infections. It serves as a protective mechanism necessary for the body's healing and infection reduction. The process involves the production of pro-inflammatory mediators, recruitment of immune cells, and tissue destruction, leading to redness, heat, pain, and swelling. Interleukin-1β (IL-1β) is a key mediator, inducing various responses in the acute phase. Prednisolone acetate is a corticosteroid medication known for its potent anti-inflammatory properties. It works by inhibiting the release of inflammatory mediators and suppressing the activity of immune cells involved in the inflammatory response.
Fig.3 Inflammatory pathway and different key inhibitors of inflammation. (Sharma, et al., 2020)
At CD BioGlyco, leveraging advanced analytical techniques and a proficient team, we guarantee accurate results for quality assurance and compliance with regulatory standards. Trust CD BioGlyco for reliable analysis services, contact us for more information about our service.
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