GF 109203X

Synonym: 133052-90-1; GF-109203X; GF109203X; GO6850; GO-6850; Bisindolylmaleimide I

CAS Number: 133052-90-1
PubChem CID: 2396

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GF 109203X, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβ1, EGFR, insulin receptor, PDGFR, PKCβ2, and PKCγ.

Molecular Weight

412.49

Molecular Formula

C₂₅H₂₄N₄O₂

Targets

PKCα: 20 nM; PKCβ1: 17 nM; EGFR: >100 μM; Insulin receptor: >100 μM; PDGFR: 65 μM; PKCβ2: 16 nM; PKCγ: 20 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 70 mg/mL (169.7 mM); Water: insoluble; Ethanol: insoluble

Applications

GF 109203X can be used as a lead compound in the development of pharmacological agents targeting PKC inhibition.