Properties
Description
Glasdegib (PF-04449913), soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets Smoothened.
Molecular Formula
C21H22N6O
Solubility
DMSO: 46 mg/mL (122.85 mM); Water: insoluble; Ethanol: insoluble
Applications
Glasdegib can be studied for its effect on blocking a specific signaling pathway that is overactive in certain types of cancer cells, including AML cells.
