Glycan Methylation Inhibitor Development

Glycan Methylation Inhibitor Development at CD BioGlyco

Methylation modifications of glycans have important effects on a variety of cellular processes, and similarly, inhibition of glycan methylation affects processes such as regulation of cell signaling and senescence. At CD BioGlyco, we provide high-quality glycan methylation inhibitor development services.

The glycan methylation pathway involves the interaction of multiple enzymes and substrates. Methyltransferases are required for the methylation of glycans. Methyltransferases transfer methyl groups to the glyoxylate residues of polysaccharides to induce methylation of glycans. To inhibit the methylation of glycans, we start with methyltransferases.

• Identification and screening of inhibitors
  We perform high-pass screening based on existing databases to collect molecules with methyltransferase binding ability, construct inhibitor libraries, and test their inhibitory potential. Then, we add these compounds to cells or organisms and determine their inhibitory capacity by measuring the binding and removal ability of these molecules to methyltransferases. In this process, we offer methods such as luciferase assays as well as fluorescent probes, fluorescent labeling, and more.
• Performance testing of inhibitors
  Methylation of glycans occurs in several bacteria, fungi, plants, and mollusks. We use bioassay techniques (gas chromatography with different derivatization schemes, liquid chromatography, mass spectrometry, and several nuclear magnetic resonance techniques) to determine the inhibitory effect of inhibitors on methylation in various organisms, and to develop inhibitors for attenuating the activity of methyltransferases, or for occupying the methylation sites of polysaccharides and thus inhibiting the methylation of glycans.

Fig.1 Glycan methylation inhibitor development. (CD BioGlyco)

Applications

• Methylation inhibitors of glycans can be used to regulate cell signaling and affect protein interactions.
• Methylation inhibitors of glycans can be used to explore epigenetic mechanisms in organisms.
• Methylation inhibitors of glycans can be used to investigate specific diseases.

Advantages

• Our proven Glycosylation Inhibitor Development Service provides our clients with the development of many types of methylation inhibitors for glycans, with a comprehensive R&D program for each type of inhibitor.
• We have a responsive research team with a high degree of sensitivity to knowledge related to the development of glycosylation inhibitors.
• We have a powerful resource platform and data processing system to ensure that our clients save time and effort.

CD BioGlyco provides comprehensive glycosylation inhibitor development services based on professional knowledge. The services we provide to our clients include but are not limited to, basic research, protocol development, experimentation, and data processing. Each of our processes is quality-tested to ensure client satisfaction. To learn more about our R&D services, please contact us.