Overview of Glyconanoparticle Absorption Study

Relying on the high-quality GlycoNano™ Platform, CD BioGlyco provides satisfactory Glyconanoparticle Preclinical Study programs. As a novel drug delivery system, glyconanoparticles have unique physicochemical properties and biocompatibility, which improve the solubility, permeability, and stability of drugs, thus enhancing their efficacy and reducing side effects. However, their pharmacokinetic properties in organisms, especially the absorption process, have an important impact on the effectiveness and safety of drugs. Therefore, it is important to carry out absorption study services on the pharmacokinetics of glyconanoparticles to guide drug design, optimize dosing regimens, and improve therapeutic efficacy. With advanced technology and a professional team, CD BioGlyco provides professional glyconanoparticle absorption study services.

In-depth Insight: Pharmacokinetic Absorption Study of Glyconanoparticles

In Vitro Simulation Studies

Our company provides services for water solubility assessment, permeability studies, and transporter studies.

• Permeability studies
  • Our company offers non-cellular models (PAMPA) and a variety of cellular models for permeability studies. The cell types we commonly use include but are not limited to, wild-type Madin-Darby canine kidney type II (MDCK-II) cells, multidrug resistance 1 (MDR1)-MDCK II cells, melanoma cells, opossum kidney (OK) cells, human bronchial epithelial (HBE) cells, and Caco-2 cells.
  • In vitro permeability assays provide permeability data including compound solubility, cellular accumulation, efflux transport, and the ability to regulate intercellular tight junctions. We offer specialized uni- and bi-directional and concentration-dependent permeability analysis services.
• Transporter studies
  • Transporters influence in vivo processes such as drug absorption, distribution, and elimination, which in turn affects drug efficacy and safety. We offer a variety of in vitro models for the evaluation of transporter-mediated drug-drug interactions. We focus on the evaluation of substrates or inhibitors for specific transporters. Cell types commonly used in our company include human embryonic kidney cells (HEK 293 cells), MDR1-MDCK I and MDR1-MDCK II cells, and Caco-2 cells.

In Vivo Metabolic Studies

• Bioavailability assessment
  • Carrier-based nanomedicines enter the body through various routes of administration such as intravenous, subcutaneous, or intramuscular, and the route of administration is an important factor in determining the absorption of nanomedicines.
  • Our researchers provide an analysis of the effect of different routes of administration such as intravenous, intraperitoneal, subcutaneous, intradermal, intrathecal, etc. on absorption.
• Blood and tissue testing
  • The difference between carrier-based nanomedicine and ordinary drugs is the existence of its functional unit drug-carrying particles. Our company offers services for the determination of the concentration of free and loaded drugs in the blood.
  • We provide the service of measuring the concentration of carrier materials and drug-carrying particles in the blood, which helps clients analyze in-depth information about the release kinetics of drugs and the depolymerization/degradation kinetics of carriers in vivo.
  • Specifically, for some nanocarrier drugs (e.g., polyethylene glycolized drug-carrying particles), the phenomenon of accelerated blood clearance (ABC) occurs in vivo after multiple injections. We offer specialized ABC monitoring services.
  • Our researchers offer somatic small bowel perfusion studies and gastrointestinal stability (chemical, microbiological, enzymatic) studies.

Workflow

Applications

• Our absorption study can be used to investigate the cellular pharmacokinetic-pharmacodynamic correlation of glyconanoparticles.
• Our absorption study can be used to analyze drug permeation and transport pathways to interpret drug absorption and distribution in the body.
• Our absorption study can be used to evaluate and predict the efficacy of drugs and the toxic side effects they may cause.

Advantages of Us

• Our absorption study provides not only bioavailability prediction but also distribution prediction of the compound in the organism, e.g., prediction of the permeability of the compound in the central system or blood-brain barrier.
• Our company offers a wide range of animal models, cellular models, and in-cohort injections to meet the needs of our clients in different studies.
• Our company has a professional data analysis team to help clients organize and analyze all experimental data.

Publication Data

Frequently Asked Questions

• What are the applications of glyconanoparticles in medicine and health?
  The research of glyconanoparticles in the field of medicine and health mainly focuses on cell separation and immunoassay, DNA isolation, nucleic acid hybridization, guided drug carriers, targeted drugs, immobilized enzymes, nuclear magnetic resonance (NMR) contrast agents, drug-carrying systems, and tumor-targeted therapies.
• How do glyconanoparticles enter cells?
  Glyconanoparticles enter the cell mainly through endocytosis, and their endocytosis pathways include giant cytosol, lattice protein-mediated endocytosis, folliculin-mediated endocytosis, and lattice protein/folliculin-independent endocytosis. The endocytosis process is closely related to both the nature of the nanoparticle itself and the nature of the cell. Our company provides services to analyze the effect of surface charge, particle size, shape, and nature of the carrier on endocytosis.

CD BioGlyco provides professional glyconanoparticle absorption study services and helps clients solve problems encountered in Pharmacokinetic Studies. Our high-quality research platforms and careful, patient service have been praised by clients all over the world. Feel free to contact us to customize your research program!