Properties
Description
GO6983, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβ, PKCδ, PKCγ, PKCμ, and PKCζ.
Molecular Formula
C26H26N4O3
Targets
PKCα: 7 nM; PKCβ: 7 nM; PKCδ: 10 nM; PKCγ: 6 nM; PKCμ: 20 μM; PKCζ: 60 nM
Solubility
DMSO: 55 mg/mL (124.29 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
GO6983 can be used to help elucidate the functions of this enzyme in processes such as cell proliferation, differentiation, apoptosis, and neurotransmitter release.
Storage
Store at -20℃, and keep desiccated.
