GPR inhibitor APD668, Purity ≥98%

Synonym: 832714-46-2; GPR inhibitor; APD 668; APD-668; JNJ-28630368; JNJ28630368; JNJ 28630368

MDL: MFCD12032117
CAS Number: 832714-46-2
Compound CID: 11705608

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

APD668, soluble in DMSO and ethanol and insoluble in water, is a compound that specifically targets and inhibits G protein-coupled receptors (GPRs), which play a critical role in transmitting signals across cell membranes. It targets CYP2C9, hERG channel, hGPR119, and rGPR119.

Molecular Weight

477.51

Molecular Formula

C₂₁H₂₄FN₅O₅S

Targets

CYP2C9: 0.1 μM (Ki); hERG channel: 3 μM; hGPR119: 2.7 μM; rGPR119: 33 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (180.1 mM); Water: Insoluble; Ethanol: 86 mg/mL (180.1 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

APD668 is studied in the context of its inhibitory effects on certain GPR receptors, relevant to diabetes and metabolic research.