GSK-3 inhibitor CHIR-98014, Purity ≥98%

Synonym: 252935-94-7; CHIR98014; GSK-3 inhibitor

CAS Number: 252935-94-7
Compound CID: 53396311

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CHIR-98014, soluble in warmed DMSO and insoluble in water and ethanol, modulates various cellular processes, including glucose metabolism, inflammation, and cell proliferation, with potential applications in treating diseases like diabetes and neurodegenerative disorders. It targets GSK-3α, P70S6K, Akt1, bFGFR, c-Src, Cdc2, Chk1, CK1ε, DNA-PK, ERK2, and FLT1.

Molecular Weight

486.3

Molecular Formula

C₂₀H₁₇Cl₂N₉O₂

Targets

GSK-3α: 0.65 nM; P70S6K: >1 μM; Akt1: >5 μM; bFGFR: >1 μM; c-Src: >1 μM; Cdc2: 3.7 μM; Chk1: >10 μM; CK1ε: >5 μM; DNA-PK: >10 μM; ERK2: >10 μM; FLT1: >5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 7 mg/mL (14.39 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

CHIR-98014 is used to analyze its effects on GSK-3 inhibition in cellular processes.

Storage

Store at -20ºC.