GSK-3 inhibitor CHIR-99021 monohydrochloride, Purity ≥98%

Synonym: 1797989-42-4; CHIR99021; CHIR 99021; CT99021 monohydrochloride; CT 99021; CT-99021; GSK-3 inhibitor

CAS Number: 1797989-42-4
Compound CID: 71295844

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CHIR-99021 monohydrochloride, soluble in DMSO and ethanol and insoluble in water, modulates various cellular processes, including glucose metabolism, inflammation, and cell proliferation, with potential applications in treating diseases like diabetes and neurodegenerative disorders. It targets cdc2, GSK-3α, and GSK-3β.

Molecular Weight

501.8

Molecular Formula

C₂₂H₁₉Cl₃N₈

Targets

cdc2: 8800 nM; GSK-3α: 10 nM; GSK-3β: 6.7 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (177.36 mM); Water: Insoluble; Ethanol: 2 mg/mL (3.98 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

CHIR-99021 monohydrochloride is used to study GSK-3 inhibition in cellular differentiation.

Storage

Store at -20ºC.