GSK-3 inhibitor CHIR-99021, Purity ≥98%

Synonym: 252917-06-9; GSK-3 inhibitor XVI; CT 99021; CHIR99021; GSK-3 inhibitor

CAS Number: 252917-06-9
Compound CID: 9956119

Product Size

2 mg; 5 mg; 25 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CHIR-99021, soluble in warmed DMSO and insoluble in water and ethanol, modulates various cellular processes, including glucose metabolism, inflammation, and cell proliferation, with potential applications in treating diseases like diabetes and neurodegenerative disorders. It targets GSK-3α and GSK-3β.

Molecular Weight

465.3

Molecular Formula

C₂₂H₁₈Cl₂N₈

Targets

GSK-3α: 10 nM; GSK-3β: 6.7 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 9 mg/mL (19.33 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

CHIR-99021 is utilized to inhibit GSK-3 in stem cell research and regenerative medicine.