Properties
Description
CHIR-99021, soluble in warmed DMSO and insoluble in water and ethanol, modulates various cellular processes, including glucose metabolism, inflammation, and cell proliferation, with potential applications in treating diseases like diabetes and neurodegenerative disorders. It targets GSK-3α and GSK-3β.
Molecular Formula
C22H18Cl2N8
Targets
GSK-3α: 10 nM; GSK-3β: 6.7 nM
Solubility
Warmed DMSO: 9 mg/mL (19.33 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CHIR-99021 is utilized to inhibit GSK-3 in stem cell research and regenerative medicine.