GSK-3 inhibitor Indirubin-3-monoxime, Purity ≥98%

Synonym: 160807-49-8; INDIRUBIN-3'-MONOXIME; Indirubin-3'-oxime; Indirubin-3-monoxime; Indirubin-3-oxime; GSK-3 inhibitor

CAS Number: 160807-49-8
Compound CID: 3707

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Indirubin-3-monoxime, soluble in DMSO and insoluble in ethanol and water, modulates various cellular processes, including glucose metabolism, inflammation, and cell proliferation, with potential applications in treating diseases like diabetes and neurodegenerative disorders. It targets 5-LOX, CDK1/cyclin B, CDK5/p25, and GSK-3β.

Molecular Weight

277.28

Molecular Formula

C₁₆H₁₁N₃O₂

Targets

5-LOX: 7.8-10 μM; CDK1/cyclin B: 180 μM; CDK5/p25: 100 μM; GSK-3β: 22 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 53 mg/mL (191.14 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Indirubin-3-monoxime is used to analyze its role in inhibiting GSK-3 and cell growth.