Properties
Description
SB 216763, soluble in DMSO and insoluble in ethanol and water, modulates various cellular processes, including glucose metabolism, inflammation, and cell proliferation, with potential applications in treating diseases like diabetes and neurodegenerative disorders. It targets GSK-3α and GSK-3β.
Molecular Formula
C19H12Cl2N2O2
Targets
GSK-3α: 34.3 nM; GSK-3β: 34.3 nM
Solubility
DMSO: 21 mg/mL (56.56 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
SB 216763 is employed to inhibit GSK-3 and study its role in neurodevelopment and cancer.
