Properties
Description
Guanabenz acetate, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets α2a-adrenergic receptor, α2b-adrenergic receptor, and α2c-adrenergic receptor.
Molecular Formula
C10H12Cl2N4O2
Targets
α2A-adrenergic receptor: 8.25 (pEC50); α2B-adrenergic receptor: 7.01 (pEC50); α2C-adrenergic receptor: <5 (pEC50)
Solubility
DMSO: 56 mg/mL (192.35 mM); Water: insoluble; Ethanol: 5 mg/mL (17.17 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Guanabenz acetate can be used for its calming effect on certain parts of the brain involved in migraine pathophysiology, potentially reducing the frequency and severity of migraine attacks.
Storage
Store at -20°C, and keep desiccated.
