HDAC inhibitor Abexinostat, Purity ≥98%

Synonym: 783355-60-2; ABEXINOSTAT; PCI-24781; PCI 24781; CRA-024781; CRA 024781; CRA-02478; HDAC inhibitor

MDL: MFCD10565969
CAS Number: 783355-60-2
Compound CID: 11749858

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Abexinostat, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC2, HDAC3/SMRT, HDAC6, and HDAC8.

Molecular Weight

397.4

Molecular Formula

C₂₁H₂₃N₃O₅

Targets

HDAC1: 7 nM (Ki); HDAC10: 24 nM; HDAC2: 19 nM (Ki); HDAC3/SMRT: 8.2 nM (Ki); HDAC6: 17 nM (Ki); HDAC8

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 72 mg/mL (181.16 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Abexinostat is used in research to explore its potential as a pan-HDAC inhibitor for cancer treatment.