Properties
Description
BRD 73954, soluble in DMSO and warmed ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC2, HDAC4, HDAC6, and HDAC8.
Molecular Formula
C16H16N2O3
Targets
HDAC2: 9 μM; HDAC4: >33 μM; HDAC6: 36 μM; HDAC8: 120 nM
Solubility
DMSO: 49 mg/mL (172.34 mM); Water: Insoluble; Warmed ethanol: 8 mg/mL (28.13 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BRD 73954 can be used to study selective HDAC inhibition.