Properties
Description
CHDI-390576 induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, hHDAC6, and hHDAC9.
Molecular Formula
C19H13F4N3O2
Targets
HDAC1: 39.7 μM; HDAC3: 25.8 μM; HDAC4: 54 nM; HDAC5: 60 nM; HDAC7: 31 nM; HDAC8: 9.1 μM; hHDAC6: 6.2 μM; hHDAC9: 50 μM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CHDI-390576 is employed to investigate its efficacy as an HDAC inhibitor in pre-clinical models of neurodegenerative diseases such as Huntington's disease.