HDAC inhibitor CHDI-390576, Purity ≥98%

Synonym: 936221-33-9; 2-(2-Fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide; 2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide; HDAC inhibitor

CAS Number: 1629729-98-1
Compound CID: 81689842

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CHDI-390576 induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, hHDAC6, and hHDAC9.

Molecular Weight

391.33

Molecular Formula

C₁₉H₁₃F₄N₃O₂

Targets

HDAC1: 39.7 μM; HDAC3: 25.8 μM; HDAC4: 54 nM; HDAC5: 60 nM; HDAC7: 31 nM; HDAC8: 9.1 μM; hHDAC6: 6.2 μM; hHDAC9: 50 μM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

CHDI-390576 is employed to investigate its efficacy as an HDAC inhibitor in pre-clinical models of neurodegenerative diseases such as Huntington's disease.