Properties
Description
CUDC-101, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC, HDAC1, EGFR, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, and HDAC7.
Molecular Formula
C24H26N4O4
Targets
HDAC: 4.4 nM; HDAC1: 4.5 nM; EGFR: 2.4 nM; HDAC10: 26.1 nM; HDAC2: 12.6 nM; HDAC3: 9.1 nM; HDAC4: 13.2 nM; HDAC5: 11.4 nM; HDAC6: 5.1 nM; HDAC7: 373 nM
Solubility
DMSO: 20 mg/mL (46.03 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CUDC-101 is used to explore its dual inhibition of HDACs and epidermal growth factor receptor (EGFR), promoting research into its therapeutic potential in cancer.
