HDAC inhibitor CUDC-101, Purity ≥98%

Synonym: 1012054-59-9; CUDC-101; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; HDAC inhibitor

MDL: MFCD15528940
CAS Number: 1012054-59-9
Compound CID: 24756910

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CUDC-101, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC, HDAC1, EGFR, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, and HDAC7.

Molecular Weight

434.5

Molecular Formula

C₂₄H₂₆N₄O₄

Targets

HDAC: 4.4 nM; HDAC1: 4.5 nM; EGFR: 2.4 nM; HDAC10: 26.1 nM; HDAC2: 12.6 nM; HDAC3: 9.1 nM; HDAC4: 13.2 nM; HDAC5: 11.4 nM; HDAC6: 5.1 nM; HDAC7: 373 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 20 mg/mL (46.03 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

CUDC-101 is used to explore its dual inhibition of HDACs and epidermal growth factor receptor (EGFR), promoting research into its therapeutic potential in cancer.