HDAC inhibitor Domatinostat, Purity ≥98%

Synonym: 910462-43-0; Domatinostat; 4SC-202; 4SC-202 (free base); (E)-N-(2-Aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide; HDAC inhibitor

CAS Number: 910462-43-0
Compound CID: 15985904

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Domatinostat, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC2, and HDAC3.

Molecular Weight

447.51

Molecular Formula

C₂₃H₂₁N₅O₃S

Targets

HDAC1: 1.20 μM; HDAC2: 1.12 μM; HDAC3: 0.57 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (172.06 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Domatinostat is studied for its ability to selectively inhibit class I HDACs, contributing to research on its application in cancer treatment.