Properties
Description
Droxinostat, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9.
Molecular Formula
C11H14ClNO3
Targets
HDAC1: >20 μM; HDAC10: >20 μM; HDAC2: >20 μM; HDAC3: 16.9 μM; HDAC4: >20 μM; HDAC5: >20 μM; HDAC6: 2.47 μM; HDAC7: >20 μM; HDAC8: 1.46 μM; HDAC9: >20 μM
Solubility
DMSO: 47 mg/mL (192.86 mM); Water: Insoluble; Ethanol: 47 mg/mL (192.86 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Droxinostat is employed to investigate its inhibitory effects on HDAC6 and HDAC8, supporting research into its potential therapeutic applications in cancer and neurodegenerative diseases.
