HDAC inhibitor Droxinostat, Purity ≥98%

Synonym: 99873-43-5; Droxinostat; 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide; HDAC inhibitor

CAS Number: 99873-43-5
Compound CID: 568416

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Droxinostat, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9.

Molecular Weight

243.7

Molecular Formula

C₁₁H₁₄ClNO₃

Targets

HDAC1: >20 μM; HDAC10: >20 μM; HDAC2: >20 μM; HDAC3: 16.9 μM; HDAC4: >20 μM; HDAC5: >20 μM; HDAC6: 2.47 μM; HDAC7: >20 μM; HDAC8: 1.46 μM; HDAC9: >20 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 47 mg/mL (192.86 mM); Water: Insoluble; Ethanol: 47 mg/mL (192.86 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Droxinostat is employed to investigate its inhibitory effects on HDAC6 and HDAC8, supporting research into its potential therapeutic applications in cancer and neurodegenerative diseases.