Fimepinostat, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9.
Fimepinostat is applied in studies to assess its dual inhibition of HDACs and phosphoinositide 3-kinase (PI3K) as a strategy for treating various cancers.
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