HDAC inhibitor HPOB, Purity ≥98%

Synonym: 1429651-50-2; HPOB; N-Hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide; N-Hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide; 4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-oxidanylidene-ethyl]-~{n}-Oxidanyl-Benzamide; 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide; HDAC inhibitor

CAS Number: 1429651-50-2
Compound CID: 71532921

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

HPOB, soluble in DMSO and warmed ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC3, HDAC8, HDAC1, HDAC10, HDAC11, HDAC2, HDAC4, HDAC5, HDAC6, and HDAC7.

Molecular Weight

314.3

Molecular Formula

C₁₇H₁₈N₂O₄

Targets

HDAC3: 1.7 μM; HDAC8: 2.8 μM; HDAC1: 2.9 μM; HDAC10: 3.0 μM; HDAC11: 3.0 μM; HDAC2: 4.4 μM; HDAC4: >10 μM; HDAC5: >10 μM; HDAC6: 56 nM; HDAC7: >10 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 60 mg/mL (190.87 mM); Water: Insoluble; Warmed ethanol: 37 mg/mL (117.7 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

HPOB is investigated for its role as an HDAC6 inhibitor, providing insights into its potential therapeutic use in cancer and neurodegenerative diseases.