HDAC inhibitor ITF2357 (Givinostat), Purity ≥98%

Synonym: 732302-99-7; Givinostat hydrochloride monohydrate; ITF2357; Givinostat (ITF2357); ITF2357 (Givinostat); Givinostat hydrochloride hydrate; (6-((Diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate; HDAC inhibitor

MDL: MFCD28502062
CAS Number: 732302-99-7
Compound CID: 9804991

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ITF2357 (Givinostat), soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HD1-B, HD1-B, and HD1-A.

Molecular Weight

476

Molecular Formula

C₂₄H₂₇N₃O₄.HCl.H₂O

Targets

HD1-B: 7.5 nM; HD1-B: 10 nM; HD1-A: 16 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 94 mg/mL (197.49 mM); Water: Insoluble; Ethanol: 3 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

ITF2357 (Givinostat) is researched for its broad-spectrum HDAC inhibitory effects and therapeutic applications, particularly in cancer and inflammatory disease contexts.

Storage

Store at -20ºC.