HDAC inhibitor Rocilinostat, Purity ≥98%

Synonym: 1316214-52-4; Ricolinostat; ACY-1215; Rocilinostat; 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; HDAC inhibitor

MDL: MFCD22666356
CAS Number: 1316214-52-4
Compound CID: 53340666

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Rocilinostat, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC2, HDAC3, HDAC1, HDAC11, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, and Sirtuin1.

Molecular Weight

433.5

Molecular Formula

C₂₄H₂₇N₅O₃

Targets

HDAC2: 48nM; HDAC3: 51 nM; HDAC1: 58 nM; HDAC11: >10 μM; HDAC4: 7 μM; HDAC5: 5 μM; HDAC6: 4.7 nM; HDAC7: 1.4 μM; HDAC8: 100 nM; HDAC9: >10 μM; Sirtuin1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 73 mg/mL (168.39 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Rocilinostat can be used to study its inhibitory effects on HDAC6 in various diseases.