Properties
Description
Santacruzamate A, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC2, HDAC4, and HDAC6.
Molecular Formula
C15H22N2O3
Targets
HDAC2: 119 pM; HDAC4: >1000 nM; HDAC6: 434 pM
Solubility
DMSO: 47 mg/mL (168.85 mM); Water: Insoluble; Ethanol: 47 mg/mL (168.85 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Santacruzamate A is used to study its selective inhibition of HDAC2, relevant to neurodegenerative and cancer research.