HDAC inhibitor Splitomicin, Purity ≥98%

Synonym: 5690-03-9; Splitomicin; Splitomycin; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1,2-Dihydro-3H-benzo[f]chromen-3-one; 1,2-Dihydrobenzo[f]chromen-3-one; 1H-Benzo[f]chromen-3(2H)-one; HDAC inhibitor

MDL: MFCD08705254
CAS Number: 5690-03-9
Compound CID: 5269

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Splitomicin, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets Sir2p.

Molecular Weight

198.22

Molecular Formula

C₁₃H₁₀O₂

Targets

Sir2p: 60 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 37 mg/mL (186.66 mM); Water: Insoluble; Ethanol: 37 mg/mL (186.66 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Splitomicin is employed in studies focusing on the inhibition of SIRT2, a class III HDAC, relevant to cancer and neurodegenerative research.