HDAC inhibitor Tinostamustine, Purity ≥98%

Synonym: 1236199-60-2; Tinostamustine; EDO-S101; EDO-S 101; EDO-S-101; Tinostamustine [USAN]; HDAC inhibitor

CAS Number: 1236199-60-2
Compound CID: 46836227

Product Size

1 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Tinostamustine, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC2, HDAC3, HDAC6, and HDAC8.

Molecular Weight

415.359

Molecular Formula

C₁₉H₂₈Cl₂N₄O₂

Targets

HDAC1: 9 nM; HDAC10: 72 nM; HDAC2: 9 nM; HDAC3: 25 nM; HDAC6: 6 nM; HDAC8: 107 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 12 mg/mL (28.89 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.81 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Tinostamustine is used to explore dual inhibition of HDAC and DNA repair enzymes, potentially enhancing cancer therapy efficacy.