Properties
Description
Tinostamustine, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC2, HDAC3, HDAC6, and HDAC8.
Molecular Formula
C19H28Cl2N4O2
Targets
HDAC1: 9 nM; HDAC10: 72 nM; HDAC2: 9 nM; HDAC3: 25 nM; HDAC6: 6 nM; HDAC8: 107 nM
Solubility
DMSO: 12 mg/mL (28.89 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.81 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Tinostamustine is used to explore dual inhibition of HDAC and DNA repair enzymes, potentially enhancing cancer therapy efficacy.
