HDAC inhibitor TMP 195, Purity ≥98%

Synonym: 1314891-22-9; TMP195; TFMO 2; TMP-195; N-(2-Methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-[2-Methyl-2-(2-phenyl-1,3-oxazol-4-yl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; HDAC inhibitor

CAS Number: 1314891-22-9
Compound CID: 67324851

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

TMP 195, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9.

Molecular Weight

456.42

Molecular Formula

C₂₃H₁₉F₃N₄O₃

Targets

HDAC4: 111 nM; HDAC5: 106 nM; HDAC6: 47800 nM; HDAC7: 46 nM; HDAC8: 11700 nM; HDAC9: 9 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 79 mg/mL (173.08 mM); Water: Insoluble; Ethanol: 79 mg/mL (173.08 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

TMP 195 can be employed in research to study the selective inhibition of class IIa HDACs and its effects on immune modulation and cancer.