HDAC inhibitor TMP 269, Purity ≥98%

Synonym: 1314890-29-3; TMP269; N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; TMP-269; N-{[4-(4-Phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; HDAC inhibitor

MDL: MFCD26522023
CAS Number: 1314890-29-3
Compound CID: 53344908

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TMP 269, soluble in DMSO and warmed ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC3 and HDAC1.

Molecular Weight

514.52

Molecular Formula

C₂₅H₂₁F₃N₄O₃S

Targets

HDAC3: 5 nM (Ki); HDAC1: 32 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (172.97 mM); Water: Insoluble; Warmed ethanol: 2 mg/mL (3.88 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

TMP 269 is utilized to investigate the inhibition of specific HDAC subclasses, particularly class IIb HDACs, in cellular differentiation and disease models.

Storage

Store at -20ºC.