HDAC inhibitor Tubastatin A HCl, Purity ≥98%

Synonym: Tubastatin A hydrochloride; Tubastatin A HCl; 1310693-92-5; Tubastatin A (Hydrochloride); UHCM2AYJVX; TSA HCl; N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide; HDAC inhibitor

MDL: MFCD20488052
CAS Number: 1310693-92-5, 1239262-52-2
Compound CID: 57336514

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Tubastatin A HCl, soluble in DMSO and insoluble in ethanol and water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC8, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, and HDAC7.

Molecular Weight

371.9

Molecular Formula

C₂₀H₂₁N₃O₂.HCl

Targets

HDAC1: 16.4 μM; HDAC8: 854 μM; HDAC10: >30 μM; HDAC11: >30 μM; HDAC2: >30 μM; HDAC3: >30 μM; HDAC4: >30 μM; HDAC5: >30 μM; HDAC6: 15 nM; HDAC7: >30 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 67 mg/mL (180.17 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Tubastatin A HCl is employed to explore selective HDAC6 inhibition and its effects on neurodegeneration, inflammation, and cancer.

Storage

Store at -20ºC.