Properties
Description
Tucidinostat, soluble in DMSO and ethanol and insoluble in water, induces DNA damage and the inhibition of DNA repair processes. It targets HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, and HDAC8.
Molecular Formula
C22H19FN4O2
Targets
HDAC1: 95 nM; HDAC10: 78 nM; HDAC11: 432 nM; HDAC2: 160 nM; HDAC3: 67 nM; HDAC8: 733 nM
Solubility
DMSO: 69 mg/mL (176.73 mM); Water: Insoluble; Ethanol: 2 mg/mL (5.12 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Tucidinostat, an HDAC inhibitor, is used in research to determine its effectiveness in treating hematologic malignancies and solid tumors.