Heparin is a natural anticoagulant that is commonly used to prevent diseases such as thrombosis. Heparin lock flush solution is an injectable solution that is commonly used to maintain the patency of intraventricular lines and prevent thrombosis. It consists mainly of heparin and saline, which has an anticoagulant effect that inhibits blood clotting, thus maintaining the patency of the intraventricular line. CD BioGlyco has been dedicated to delivering exceptional Pharmaceutical Analysis Services to our esteemed clients for an extensive period, and our services have garnered high acclaim from our valued clientele. Currently, there are several methods available for the analysis of heparin lock flushes. These include physicochemical methods, chromatography methods, spectroscopic methods, and biological assays. We utilize these technologies to provide you with superior heparin lock flush solution analysis services.
Fig.1 Analytical approach to heparin lock flush solution. (CD BioGlyco)
Technology: Anti-Xa assay and GC
Journal: Journal of Pediatric Surgery
IF: 2.4
Published: 2015
Results: This article examines the chemical stability of heparin, isopropanol, and ethanol line lock solutions. The article explores the chemical and physical stability of these solutions in central venous catheters over 10 days at 2-8°C and 25°C. Samples were prepared over 10 days and stored in a refrigerator at 2-8°C or in a 60% relative humidity cabinet at 25°C. Before any analysis, sample syringes were subjected to a standard mixing process in which 1 mL of air was withdrawn, a combi-stopper was attached, and the syringe was inverted 10 times. The researchers analyzed the samples for visible particle counting using the CLIMET particle counting system to assess the number of particles in solution and analyzed the concentration of heparin in the samples using the anti-Xa assay. The results of the study showed that the addition of isopropanol to heparin and ethanol prevented the formation of precipitates. However, the activity of heparin gradually decreased over time, making this solution unsuitable for prolonged storage.
Fig.2 The applications of heparin. (Zang, et al., 2022)
CD BioGlyco remains committed not only to providing efficient heparin lock flush solution analysis service but also to ensuring timely project completion. We maintain streamlined processes that minimize turnaround times without compromising quality. Please feel free to contact us for more details.
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