Properties
Description
2-Methoxyestradiol, soluble in DMSO and insoluble in ethanol and water, is designed to disrupt the hypoxia-inducible factor (HIF) pathway, aiming to hinder cancer cell survival and adaptation in low-oxygen environments characteristic of tumor growth. It targets HIF-1α (MDA-MB-231 cells), HIF-2α (Rat aortic smooth muscle A-10 cells), and HIF-2α (rat aortic smooth muscle A-10 cells).
Molecular Formula
C19H26O3
Targets
HIF-1α (MDA-MB-231 cells); HIF-2α (Rat aortic smooth muscle A-10 cells); HIF-2α (Rat aortic smooth muscle A-10 cells)
Solubility
DMSO: 55 mg/mL (181.87 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
2-Methoxyestradiol is commonly researched for its effects on angiogenesis and tumor growth inhibition under hypoxic conditions.
